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Jan 31, 2009
Jan 24, 2009
Longevity escape velocity
Aubrey de Grey, a British biomedical gerontologist, states in his book "Ending Aging," that that the fundamental knowledge to develop effective anti-aging medicine mostly already exists.
In a Ted Show presentation he states:
Age damage
There are seven types of aging damage :
Although, for more than 25 years, science suspiciously didn't seem to develop, all kind of medicines to repair these damages are already within reach for mice.
Age damage for human beings is strongly age related:
As the chairman of the Methuselah-Foundation, De Grey stimulates scientists to develop medicines that repair age damage for this living generation.
Experiments on mouses showed that medicines didn't only slow down the aging process, but could reverse it as well (condition: start in time!). It turns out that every time a new medicine is developed and applied, it restores - above a certain threshold of reserve capacity - the lost reserve capacity for about 50%.
This would imply that if new medicines for human beings would be developed within the next decade and the rate of developing new medicines will be fast enough to stay 'ahead of the game', all people of 50 years and younger would be able to live a thousand years or more and people just slightly older could still live for hundred years or more.
In 2006 Technology Review announced a $20,000 prize for any molecular biologist who could demonstrate that De Grey was wrong. Nobody succeeded!
If De Grey is right, actuaries don't even have to start calculating new life expectancies or other (financial) consequences. Life insurance and pension will have to be redefined.
Even stronger: We'll have to redefine our life!
Sources: Ted Show presentation, Pres. 1, Pres 2
Related links:
A model of aging as accumulated damage matches observed mortality ...
In a Ted Show presentation he states:
Why should we cure aging?
Because it kills people!
Because it kills people!
Age damage
There are seven types of aging damage :
| Damage rising with age | Proposed as contributing to aging by |
| Cell loss, cell atrophy | Brody (1955) or earlier |
| Extracellular junk | Alzheimer (1907) |
| Extracellular crosslinks | Monnier and Cerami (1981) |
| Cell senescence | Hayflick (1965) |
| Mitochondrial mutations | Harman (1972) |
| Lysosomal junk | Strehler (1959) or earlier |
| Nuclear [epi]mutations (cancer) | Szilard (1959) and Cutler (1982) |
Although, for more than 25 years, science suspiciously didn't seem to develop, all kind of medicines to repair these damages are already within reach for mice.
Age damage for human beings is strongly age related:
As the chairman of the Methuselah-Foundation, De Grey stimulates scientists to develop medicines that repair age damage for this living generation.
Experiments on mouses showed that medicines didn't only slow down the aging process, but could reverse it as well (condition: start in time!). It turns out that every time a new medicine is developed and applied, it restores - above a certain threshold of reserve capacity - the lost reserve capacity for about 50%.
This would imply that if new medicines for human beings would be developed within the next decade and the rate of developing new medicines will be fast enough to stay 'ahead of the game', all people of 50 years and younger would be able to live a thousand years or more and people just slightly older could still live for hundred years or more.
In 2006 Technology Review announced a $20,000 prize for any molecular biologist who could demonstrate that De Grey was wrong. Nobody succeeded!If De Grey is right, actuaries don't even have to start calculating new life expectancies or other (financial) consequences. Life insurance and pension will have to be redefined.
Even stronger: We'll have to redefine our life!
Sources: Ted Show presentation, Pres. 1, Pres 2
Related links:
A model of aging as accumulated damage matches observed mortality ...
Jan 19, 2009
Table Converter (Free!)
Do you recognize this? Sometimes you spend hours copying a simple table from a WORD-document, Internet Page or PDF-file to your (Excel) spreadsheet.
What should take about two minutes work, ends in frustration. Finally you decide to fill your spreadsheet by hand.
These times are over. With the next simple javascript application, called
, you'll be able to copy most tables to your spreadsheet in minutes.
Success!
What should take about two minutes work, ends in frustration. Finally you decide to fill your spreadsheet by hand.
These times are over. With the next simple javascript application, called
, you'll be able to copy most tables to your spreadsheet in minutes.
Success!
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